I only know the section from Harrisburg to Lewistown - I have driven that route many times. As you leave Harrisburg heading north, you turn left and cross the Rockville Bridge (the world's longest and widest stone arch bridge opened in 1902). Views south are of the river as it crosses Cumberland Valley and Harrisburg on the left. To the north are the several mountain ridges the Susquehanna cuts through. If you are on the right looking north as you cross the bridge, look for the Little Statue of Liberty mounted on an old bridge pier. I think it is within sight north of the Bridge, but I am not sure.Stats on the Rockville Bridge:
The bridge is built of sandstone from western Pennsylvania, primarily from quarries in Johnstown and Curwensville. Total weight is 440 million pounds (220,000 tons). Length is 3,823 feet between back walls of the abutments at the springing line. The bridge is made up of two abutments, 47 piers, and 48 arches. Each arch is 70 feet long.
At the far end of the bridge you will turn right and head north along the Susquehanna until you reach the Juniata. The views of the river and mountains will be on your right.
The Three Rivers follows the Juniata on it's left(southern) bank for most of the way to Lewistown with pretty views of the river and hills on your right.
From Lewistown toward Pittsburgh I am less familiar with the terrain, but apparently there are still many good views from the right. Enjoy.
I will be riding the Three Rivers in June on my way to the California Zephyr and Sacramento. I have never ridden it before. But I distinctly remember many trips on route 322 as a child watching the prior passenger trains and then Amtrak. 322 is to on the north side of the river and high up. At night we would see the lights in the passenger cars going along the river.
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